BAIT
PTPRD
HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA
protein tyrosine phosphatase, receptor type, D
GO Process (8)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- neuron differentiation [ISS]
- peptidyl-tyrosine dephosphorylation [TAS]
- phosphate-containing compound metabolic process [NAS]
- positive regulation of dendrite morphogenesis [ISS]
- presynaptic membrane assembly [ISS]
- protein dephosphorylation [TAS]
- transmembrane receptor protein tyrosine phosphatase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CSNK1D
ASPS, CKIdelta, FASPS2, HCKID
casein kinase 1, delta
GO Process (14)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of protein phosphorylation [IMP]
- protein phosphorylation [IDA]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
- spindle assembly [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene.
Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD, indicating a potential tumor suppressor function for this gene. ... [more]
Mol. Cancer Feb. 05, 2012; 11();6 [Pubmed: 22305495]
Throughput
- High Throughput
Additional Notes
- Protein interaction array
Curated By
- BioGRID