BAIT
PTPRD
HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA
protein tyrosine phosphatase, receptor type, D
GO Process (8)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- neuron differentiation [ISS]
- peptidyl-tyrosine dephosphorylation [TAS]
- phosphate-containing compound metabolic process [NAS]
- positive regulation of dendrite morphogenesis [ISS]
- presynaptic membrane assembly [ISS]
- protein dephosphorylation [TAS]
- transmembrane receptor protein tyrosine phosphatase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CSNK1E
CKIepsilon, HCKIE, RP1-5O6.1
casein kinase 1, epsilon
GO Process (12)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- Wnt signaling pathway [IBA]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA, ISS]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene.
Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD, indicating a potential tumor suppressor function for this gene. ... [more]
Mol. Cancer Feb. 05, 2012; 11();6 [Pubmed: 22305495]
Throughput
- High Throughput
Additional Notes
- Protein interaction array
Curated By
- BioGRID