WDR26
Gene Ontology Cellular Component
CORO1A
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- cell-substrate adhesion [IMP]
- cellular component movement [NAS]
- innate immune response [NAS]
- leukocyte chemotaxis [IBA]
- negative regulation of actin nucleation [IDA]
- phagocytosis [IMP]
- phagolysosome assembly [IMP]
- positive chemotaxis [IDA]
- regulation of cell shape [IBA]
- uropod organization [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation.
The Rac1 GTPase plays key roles in cytoskeletal organization, cell motility and a variety of physiological and disease-linked responses. Wild type Rac1 signaling entails dissociation of the GTPase from cytosolic Rac1-Rho GDP dissociation inhibitor (GDI) complexes, translocation to membranes, activation by exchange factors, effector binding, and activation of downstream signaling cascades. Out of those steps, membrane translocation is the less ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID