RAD50
Gene Ontology Biological Process
- DNA duplex unwinding [TAS]
- double-strand break repair via homologous recombination [IGI]
- double-strand break repair via nonhomologous end joining [IMP]
- gene conversion at mating-type locus, DNA repair synthesis [IMP]
- homologous recombination-dependent replication fork processing [IMP]
- intra-S DNA damage checkpoint [IMP]
- meiotic DNA double-strand break formation [IMP]
- mitotic DNA damage checkpoint [IMP]
- reciprocal meiotic recombination [IMP]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAD2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair.
To study the role of Rad50 in the DNA damage response, we cloned and deleted the Schizosaccharomyces pombe RAD50 homologue. The deletion is sensitive to a range of DNA-damaging agents and shows dynamic epistatic interactions with other recombination-repair genes. We show that Rad50 is necessary for recombinational repair of the DNA lesion at the mating-type locus and that rad50Delta shows ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD50 RAD2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - |
Curated By
- BioGRID