BAIT
NR4A1
GFRP1, Gfrp, Hbr-1, Hbr1, Hmr, N10, NGFI-B, NGFIB, NP10, TIS1, TR3, nur77
nuclear receptor subfamily 4, group A, member 1
GO Process (14)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [IMP]
- cell migration involved in sprouting angiogenesis [ISO]
- cellular response to fibroblast growth factor stimulus [ISO]
- cellular response to organic substance [IDA]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- endothelial cell chemotaxis [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- response to inorganic substance [ISA]
- skeletal muscle cell differentiation [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
FGF2
BFGF, FGF-2, FGFB, HBGF-2
fibroblast growth factor 2 (basic)
GO Process (40)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPK activity [TAS]
- branching involved in ureteric bud morphogenesis [IDA]
- cell migration involved in sprouting angiogenesis [IDA, IGI]
- chemotaxis [TAS]
- chondroblast differentiation [IDA]
- embryonic morphogenesis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- hyaluronan catabolic process [IDA]
- innate immune response [TAS]
- inositol phosphate biosynthetic process [IDA]
- insulin receptor signaling pathway [TAS]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast migration [IDA]
- negative regulation of wound healing [IDA]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- phosphatidylinositol biosynthetic process [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell fate specification [IDA]
- positive regulation of cell proliferation [IGI]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of angiogenesis [TAS]
- release of sequestered calcium ion into cytosol [IDA]
- signal transduction [NAS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
A novel nuclear FGF Receptor-1 partnership with retinoid and Nur receptors during developmental gene programming of embryonic stem cells.
FGF Receptor-1 (FGFR1), a membrane-targeted protein, is also involved in independent direct nuclear signaling. We show that nuclear accumulation of FGFR1 is a common response to retinoic acid (RA) in pluripotent embryonic stem cells (ESC) and neural progenitors and is both necessary and sufficient for neuronal-like differentiation and accompanying neuritic outgrowth. Dominant negative nuclear FGFR1, which lacks the tyrosine kinase ... [more]
J. Cell. Biochem. Sep. 01, 2012; 113(9);2920-36 [Pubmed: 22539306]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID