BAIT

DCAF11

PRO2389, WDR23, GL014

DDB1 and CUL4 associated factor 11

GO Process (1)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

protein ubiquitination [IC]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

Cul4-RING E3 ubiquitin ligase complex [IDA]

nucleoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

AIFM1

AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8, RP3-438D16.2

apoptosis-inducing factor, mitochondrion-associated, 1

GO Process (9)

GO Function (4)

GO Component (5)

Gene Ontology Biological Process

DNA catabolic process [TAS]

activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]

apoptotic DNA fragmentation [TAS]

apoptotic process [IMP]

chromosome condensation [TAS]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]

mitochondrial respiratory chain complex I assembly [IMP]

neuron differentiation [IDA]

positive regulation of apoptotic process [TAS]

Gene Ontology Molecular Function

NAD(P)H oxidase activity [TAS]
electron carrier activity [TAS]
oxidoreductase activity, acting on NAD(P)H [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

mitochondrial inner membrane [TAS]

mitochondrial intermembrane space [IDA, IMP]

mitochondrion [IDA]

nucleus [IDA, ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells.

Chen Z, Wang K, Hou C, Jiang K, Chen B, Chen J, Lao L, Qian L, Zhong G, Liu Z, Zhang C, Shen H

Cell cycle progression in mammals is strictly controlled by a number of cyclin-dependent kinases (CDKs) and CDK inhibitors (CKIs), the expression of which is often dysregulated in cancer cells. Our previous work revealed that Cullin 4B (CUL4B), a critical component of the Cullin4B-RING E3 ligase complex (CRL4B), is overexpressed in human osteosarcoma cells through an unknown mechanism. Here, we demonstrated ... [more]

Sci Rep Dec. 26, 2016; 7(1);1175 [Pubmed: 28446751]

Throughput

Low Throughput

Curated By

BioGRID