BAIT

ACO2

ACONM, ICRD, RP3-347H13.8
aconitase 2, mitochondrial
GO Process (5)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

GPI

AMF, GNPI, NLK, PGI, PHI, SA-36, SA36
glucose-6-phosphate isomerase
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

Rosenbluh J, Mercer J, Shrestha Y, Oliver R, Tamayo P, Doench JG, Tirosh I, Piccioni F, Hartenian E, Horn H, Fagbami L, Root DE, Jaffe J, Lage K, Boehm JS, Hahn WC

Genome-scale expression studies and comprehensive loss-of-function genetic screens have focused almost exclusively on the highest confidence candidate genes. Here, we describe a strategy for characterizing the lower confidence candidates identified by such approaches. We interrogated 177 genes that we classified as essential for the proliferation of cancer cells exhibiting constitutive β-catenin activity and integrated data for each of the candidates, ... [more]

Cell Syst Dec. 28, 2015; 3(3);302-316.e4 [Pubmed: 27684187]

Throughput

  • High Throughput

Additional Notes

  • High-credibility protein interactions were identified using draft-PPI and a method for protein interaction credibility scoring (ICS).

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
GPI ACO2
Co-fractionation
Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

High1.6327BioGRID
2628779

Curated By

  • BioGRID