ADSS
Gene Ontology Biological Process
- 'de novo' AMP biosynthetic process [IBA]
- AMP biosynthetic process [IDA, NAS]
- IMP metabolic process [IBA]
- immune system process [NAS]
- nucleobase-containing small molecule metabolic process [TAS]
- purine nucleobase metabolic process [TAS]
- purine ribonucleoside monophosphate biosynthetic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ADSSL1
Gene Ontology Biological Process
- 'de novo' AMP biosynthetic process [IBA]
- AMP biosynthetic process [IDA]
- IMP metabolic process [IBA]
- immune system process [NAS]
- nucleobase-containing small molecule metabolic process [TAS]
- purine nucleobase metabolic process [TAS]
- purine ribonucleoside monophosphate biosynthetic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.
Genome-scale expression studies and comprehensive loss-of-function genetic screens have focused almost exclusively on the highest confidence candidate genes. Here, we describe a strategy for characterizing the lower confidence candidates identified by such approaches. We interrogated 177 genes that we classified as essential for the proliferation of cancer cells exhibiting constitutive β-catenin activity and integrated data for each of the candidates, ... [more]
Throughput
- High Throughput
Additional Notes
- High-credibility protein interactions were identified using draft-PPI and a method for protein interaction credibility scoring (ICS).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ADSS ADSSL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2217119 | |
| ADSS ADSSL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3110534 | |
| ADSSL1 ADSS | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | - | |
| ADSS ADSSL1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.0257 | BioGRID | 3584479 |
Curated By
- BioGRID