MRE11
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [TAS]
- DNA double-strand break processing [IGI, IMP]
- cellular protein localization [IMP]
- double-strand break repair [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- intra-S DNA damage checkpoint [IMP]
- meiotic DNA double-strand break formation [TAS]
- meiotic gene conversion [IDA]
- mitotic DNA damage checkpoint [IMP]
- reciprocal meiotic recombination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.
Telomeres, the ends of linear chromosomes, are DNA double-strand ends that do not trigger a cell cycle arrest and yet require checkpoint and DNA repair proteins for maintenance. Genetic and biochemical studies in the fission yeast Schizosaccharomyces pombe were undertaken to understand how checkpoint and DNA repair proteins contribute to telomere maintenance. On the basis of telomere lengths of mutant ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: telomere length (APO:0000144)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MRE11 RAD1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -9.967 | BioGRID | 522494 |
Curated By
- BioGRID