A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.

Nakamura TM, Moser BA, Russell P

Telomeres, the ends of linear chromosomes, are DNA double-strand ends that do not trigger a cell cycle arrest and yet require checkpoint and DNA repair proteins for maintenance. Genetic and biochemical studies in the fission yeast Schizosaccharomyces pombe were undertaken to understand how checkpoint and DNA repair proteins contribute to telomere maintenance. On the basis of telomere lengths of mutant ... [more]

Genetics Aug. 01, 2002; 161(4);1437-52 [Pubmed: 12196391]

Throughput

Low Throughput

Ontology Terms

phenotype: telomere length (APO:0000144)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
MRE11 RAD17	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Roguev A (2008)	High	-5.7893	BioGRID	522413

Curated By

BioGRID

Interaction Summary

MRE11

Gene Ontology Biological Process

Gene Ontology Molecular Function

double-stranded DNA 3'-5' exodeoxyribonuclease activity [TAS]manganese ion binding [IDA]nuclease activity [IDA]protein binding [IPI]single-stranded DNA 3'-5' exodeoxyribonuclease activity [TAS]single-stranded DNA endodeoxyribonuclease activity [TAS]

Gene Ontology Cellular Component

RAD17