BAIT
MOR2
cps12, SPBP19A11.04c
morphogenesis protein Mor2
GO Process (3)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
WEE1
SPCC18B5.03
M phase inhibitor protein kinase Wee1
GO Process (8)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cytokinesis after mitosis checkpoint [IGI]
- mitotic DNA damage checkpoint [IMP]
- mitotic cell cycle checkpoint [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IDA]
- peptidyl-serine autophosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IDA]
- regulation of cell size [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.
Fission yeast cells identify growing regions at the opposite ends of the cell, producing the rod-like shape. The positioning of the growth zone(s) and the polarized growth require CLIP170-like protein Tip1 and the Ndr kinase Orb6, respectively. Here, we show that the mor2/cps12 mutation disrupts the localization of F-actin at the cell ends, producing spherical cells and concomitantly inducing a ... [more]
EMBO J. Sep. 16, 2002; 21(18);4863-74 [Pubmed: 12234926]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID