BAIT

KCNA3

HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3, RP11-284N8.3
potassium voltage-gated channel, shaker-related subfamily, member 3
UPS Project
GO Process (3)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

KCNE4

MIRP3
potassium voltage-gated channel, Isk-related family, member 4
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit.

Sole L, Roig SR, Vallejo-Gracia A, Serrano-Albarras A, Martinez-Marmol R, Tamkun MM, Felipe A

The voltage-dependent K+ channel Kv1.3 (also known as KCNA3), which plays crucial roles in leukocytes, physically interacts with KCNE4. This interaction inhibits the K+ currents because the channel is retained within intracellular compartments. Thus, KCNE subunits are regulators of K+ channels in the immune system. Although the canonical interactions of KCNE subunits with Kv7 channels are under intensive investigation, the ... [more]

J. Cell. Sci. Dec. 15, 2015; 129(22);4265-4277 [Pubmed: 27802162]

Throughput

  • Low Throughput

Curated By

  • BioGRID