SCN5A
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [ISO]
- SA node cell action potential [ISO]
- SA node cell to atrial cardiac muscle cell communication [ISO]
- brainstem development [IEP]
- bundle of His cell to Purkinje myocyte communication [ISO]
- cardiac muscle cell action potential involved in contraction [ISO]
- cardiac muscle contraction [ISO]
- cardiac ventricle development [ISO]
- cellular response to calcium ion [ISO, ISS]
- cerebellum development [IEP]
- membrane depolarization [ISO]
- membrane depolarization during SA node cell action potential [ISO]
- membrane depolarization during action potential [IBA, ISO]
- membrane depolarization during cardiac muscle cell action potential [ISO]
- neuronal action potential [IBA]
- odontogenesis of dentin-containing tooth [IEP]
- positive regulation of action potential [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of heart rate [IMP]
- positive regulation of sodium ion transport [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of atrial cardiac muscle cell membrane repolarization [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of heart rate [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of sodium ion transmembrane transport [ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to denervation involved in regulation of muscle adaptation [IMP]
- response to organic cyclic compound [ISO]
- sodium ion transmembrane transport [IMP, ISO]
- sodium ion transport [ISO, ISS]
- telencephalon development [IEP]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- ankyrin binding [IDA, IPI, ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- fibroblast growth factor binding [IPI, ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- scaffold protein binding [ISO]
- ubiquitin protein ligase binding [ISO]
- voltage-gated sodium channel activity [IBA, ISO, ISS]
- voltage-gated sodium channel activity involved in SA node cell action potential [ISO]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [ISO]
- ankyrin binding [IDA, IPI, ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- fibroblast growth factor binding [IPI, ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- scaffold protein binding [ISO]
- ubiquitin protein ligase binding [ISO]
- voltage-gated sodium channel activity [IBA, ISO, ISS]
- voltage-gated sodium channel activity involved in SA node cell action potential [ISO]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [ISO]
Gene Ontology Cellular Component
KCNJ2
Gene Ontology Biological Process
- cardiac muscle cell action potential [ISO]
- cardiac muscle cell action potential involved in contraction [ISO]
- cellular response to mechanical stimulus [IEP]
- magnesium ion transport [ISO]
- membrane repolarization during action potential [ISO]
- membrane repolarization during cardiac muscle cell action potential [ISO]
- positive regulation of potassium ion transmembrane transport [IMP]
- potassium ion import [IBA, ISO]
- potassium ion transmembrane transport [ISO]
- potassium ion transport [ISO, ISS]
- protein homotetramerization [ISO, ISS]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of membrane repolarization [ISO]
- regulation of skeletal muscle contraction via regulation of action potential [ISO]
- relaxation of cardiac muscle [ISO]
- relaxation of skeletal muscle [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- T-tubule [IDA]
- dendrite [IDA]
- dendritic spine [IDA]
- integral component of plasma membrane [IBA]
- intercalated disc [IDA]
- intrinsic component of membrane [ISO, ISS]
- neuronal cell body [IDA]
- plasma membrane [IDA]
- rough endoplasmic reticulum [IDA]
- smooth endoplasmic reticulum [IDA]
- voltage-gated potassium channel complex [ISO]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Kir2.1-Nav1.5 Channel Complexes Are Differently Regulated than Kir2.1 and Nav1.5 Channels Alone.
Cardiac Kir2.1 and Nav1.5 channels generate the inward rectifier K+ (IK1) and the Na+ (INa) currents, respectively. There is a mutual interplay between the ventricular INa and IK1 densities, because Nav1.5 and Kir2.1 channels exhibit positive reciprocal modulation. Here we compared some of the biological properties of Nav1.5 and Kir2.1 channels when they are expressed together or separately to get ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNJ2 SCN5A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 2470464 | |
| SCN5A KCNJ2 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 2470461 |
Curated By
- BioGRID