KCNJ2
Gene Ontology Biological Process
- cardiac muscle cell action potential [ISO]
- cardiac muscle cell action potential involved in contraction [ISO]
- cellular response to mechanical stimulus [IEP]
- magnesium ion transport [ISO]
- membrane repolarization during action potential [ISO]
- membrane repolarization during cardiac muscle cell action potential [ISO]
- positive regulation of potassium ion transmembrane transport [IMP]
- potassium ion import [IBA, ISO]
- potassium ion transmembrane transport [ISO]
- potassium ion transport [ISO, ISS]
- protein homotetramerization [ISO, ISS]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of membrane repolarization [ISO]
- regulation of skeletal muscle contraction via regulation of action potential [ISO]
- relaxation of cardiac muscle [ISO]
- relaxation of skeletal muscle [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- T-tubule [IDA]
- dendrite [IDA]
- dendritic spine [IDA]
- integral component of plasma membrane [IBA]
- intercalated disc [IDA]
- intrinsic component of membrane [ISO, ISS]
- neuronal cell body [IDA]
- plasma membrane [IDA]
- rough endoplasmic reticulum [IDA]
- smooth endoplasmic reticulum [IDA]
- voltage-gated potassium channel complex [ISO]
CAMK2A
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO, ISS]
- calcium ion transport [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IDA]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO, ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISO, ISS]
- protein autophosphorylation [IDA, IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO, ISS]
- regulation of neuronal synaptic plasticity [ISO, ISS]
- regulation of neurotransmitter secretion [ISO, ISS]
- response to ischemia [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Kir2.1-Nav1.5 Channel Complexes Are Differently Regulated than Kir2.1 and Nav1.5 Channels Alone.
Cardiac Kir2.1 and Nav1.5 channels generate the inward rectifier K+ (IK1) and the Na+ (INa) currents, respectively. There is a mutual interplay between the ventricular INa and IK1 densities, because Nav1.5 and Kir2.1 channels exhibit positive reciprocal modulation. Here we compared some of the biological properties of Nav1.5 and Kir2.1 channels when they are expressed together or separately to get ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID