WDR48
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair via homologous recombination [IMP]
- embryonic organ development [IMP]
- homeostasis of number of cells [IMP]
- male gonad development [IMP]
- multicellular organism growth [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- protein deubiquitination [ISO]
- regulation of protein monoubiquitination [IMP]
- seminiferous tubule development [IMP]
- single fertilization [IMP]
- skeletal system morphogenesis [IMP]
- skin development [IMP]
- spermatogenesis [IMP]
Gene Ontology Cellular Component
TBK1
Gene Ontology Biological Process
- activation of innate immune response [IMP]
- defense response to Gram-positive bacterium [IMP]
- dendritic cell proliferation [IGI]
- negative regulation of gene expression [IMP]
- positive regulation of interferon-alpha production [ISO]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interferon-beta production [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
Optimal activation of TANK-binding kinase 1 (TBK1) is crucial for initiation of innate antiviral immunity and maintenance of immune homeostasis. Although several E3 ubiquitin ligases have been reported to regulate TBK1 activation by mediating its polyubiquitination, the functions of deubiquitinase on TBK1 activity remain largely unclear. Here, we identified a deubiquitinase complex, which is formed by ubiquitin specific peptidase 1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID