A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The S/M checkpoint at 37 degrees C and the recovery of viability of the mutant poldeltats3 require the crb2+/rhp9+ gene in fission yeast.

Grenon M, Tillit J, Piard K, Baldacci G, Francesconi S

We have isolated a mutant in fission yeast, in which mitosis is uncoupled from completion of DNA replication when DNA synthesis is impaired by a thermosensitive mutation in the gene encoding the catalytic subunit of DNA polymerase delta. By functional complementation, we cloned the wild-type gene and identified it as the recently cloned checkpoint gene crb2+/rhp9+. This gene has been ... [more]

Mol. Gen. Genet. Jan. 01, 1999; 260(6);522-34 [Pubmed: 9928931]

Throughput

Low Throughput

Ontology Terms

phenotype: mitotic cell cycle (APO:0000072)
phenotype: inviable (APO:0000112)

Additional Notes

double mutants show mitotic catastrophe

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CRB2 CDC27	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Grenon M (1999)	Low	-	BioGRID	247056

Curated By

BioGRID

Interaction Summary

CRB2

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

CDC27