FGF2
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPK activity [TAS]
- branching involved in ureteric bud morphogenesis [IDA]
- cell migration involved in sprouting angiogenesis [IDA, IGI]
- chemotaxis [TAS]
- chondroblast differentiation [IDA]
- embryonic morphogenesis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- hyaluronan catabolic process [IDA]
- innate immune response [TAS]
- inositol phosphate biosynthetic process [IDA]
- insulin receptor signaling pathway [TAS]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast migration [IDA]
- negative regulation of wound healing [IDA]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- phosphatidylinositol biosynthetic process [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell fate specification [IDA]
- positive regulation of cell proliferation [IGI]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of angiogenesis [TAS]
- release of sequestered calcium ion into cytosol [IDA]
- signal transduction [NAS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SNTG1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican.
The formation of distinctive basic FGF-heparan sulfate complexes is essential for the binding of bFGF to its cognate receptor. In previous experiments, cell-surface heparan sulfate proteoglycans extracted from human lung fibroblasts could not be shown to promote high affinity binding of bFGF when added to heparan sulfate-deficient cells that express FGF receptor-1 (FGFR1) (Aviezer, D., D. Hecht, M. Safran, M. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID