BAIT

RSF1

4832420A03Rik, C030033M12Rik, Gm164, Hbxap, XAP8, p325

remodeling and spacing factor 1

GO Process (8)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

DNA-templated transcription, initiation [ISO]

chromatin remodeling [ISO]

negative regulation of DNA binding [ISO]

negative regulation of transcription, DNA-templated [ISO]

nucleosome assembly [ISO]

nucleosome positioning [ISO]

positive regulation of transcription, DNA-templated [ISO]

positive regulation of viral transcription [ISO]

Gene Ontology Molecular Function

histone binding [ISO]

Gene Ontology Cellular Component

RSF complex [ISO]

nucleoplasm [ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

RNF2

AI326319, AI450156, AU019207, Ring1B, dinG

ring finger protein 2

GO Process (7)

GO Function (6)

GO Component (10)

Gene Ontology Biological Process

anterior/posterior axis specification [IMP]

gastrulation with mouth forming second [IMP]

histone H2A monoubiquitination [ISO]

histone H2A-K119 monoubiquitination [IMP]

histone ubiquitination [IDA, IGI]

mitotic cell cycle [IMP]

negative regulation of transcription from RNA polymerase II promoter [IMP]

Gene Ontology Molecular Function

RING-like zinc finger domain binding [ISO]
chromatin binding [IDA]
protein binding [IPI]
ubiquitin protein ligase activity [IDA]
ubiquitin-protein transferase activity [ISO]
zinc ion binding [ISO]

Gene Ontology Cellular Component

MLL1 complex [ISO]

PRC1 complex [ISO]

PcG protein complex [IDA, ISO]

euchromatin [IDA]

heterochromatin [IDA]

nuclear body [IDA]

nucleoplasm [ISO]

nucleus [IDA, ISO]

sex chromatin [IDA]

ubiquitin ligase complex [IDA, ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing.

Zhang Z, Jones AE, Wu W, Kim J, Kang Y, Bi X, Gu Y, Popov IK, Renfrow MB, Vassylyeva MN, Vassylyev DG, Giles KE, Chen D, Kumar A, Fan Y, Tong Y, Liu CF, An W, Chang C, Luo J, Chow LT, Wang H

Posttranslational histone modifications play important roles in regulating chromatin-based nuclear processes. Histone H2AK119 ubiquitination (H2Aub) is a prevalent modification and has been primarily linked to gene silencing. However, the underlying mechanism remains largely obscure. Here we report the identification of RSF1 (remodeling and spacing factor 1), a subunit of the RSF complex, as a H2Aub binding protein, which mediates the ... [more]

Proc. Natl. Acad. Sci. U.S.A. Sep. 19, 2017; 114(38);E7949-E7958 [Pubmed: 28855339]

Throughput

Low Throughput

Additional Notes

ChIP Assay

Curated By

BioGRID