BAIT
RAD17
SPAC14C4.13
RFC related checkpoint protein Rad17
GO Process (4)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
MCM4
SPCC24B10.01, cdc21, SPCC16A11.17
MCM complex subunit Mcm4/Cdc21
GO Process (2)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints.
To further dissect the genetic differences between the checkpoint pathway following S-phase cdc arrest versus DNA damage, a genetic screen was performed for checkpoint mutants that were unable to arrest mitosis following cell-cycle arrest with a temperature-sensitive DNA polymerase delta mutant, cdc20-M10. One such checkpoint mutant, rad17-d14, was found to display the cut phenotype following S-phase arrest by cdc20-M10, but ... [more]
J. Cell. Sci. Mar. 01, 2000; 113(0);1075-88 [Pubmed: 10683155]
Throughput
- Low Throughput
Ontology Terms
- mitotic cell cycle (APO:0000072)
Additional Notes
- double mutants display defects in mitotic cell cycle with increases in cut phenotypes
Curated By
- BioGRID