A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints.

Griffiths D, Uchiyama M, Nurse P, Wang TS

To further dissect the genetic differences between the checkpoint pathway following S-phase cdc arrest versus DNA damage, a genetic screen was performed for checkpoint mutants that were unable to arrest mitosis following cell-cycle arrest with a temperature-sensitive DNA polymerase delta mutant, cdc20-M10. One such checkpoint mutant, rad17-d14, was found to display the cut phenotype following S-phase arrest by cdc20-M10, but ... [more]

J. Cell. Sci. Mar. 01, 2000; 113(0);1075-88 [Pubmed: 10683155]

Throughput

Low Throughput

Ontology Terms

phenotype: mitotic cell cycle (APO:0000072)

Additional Notes

double mutants display defects in mitotic cell cycle with increases in cut phenotypes

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
RAD17 CDC1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Griffiths D (2000)	Low	-	BioGRID	247077

Curated By

BioGRID

Interaction Summary

RAD17

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA clamp loader activity [TAS]

Gene Ontology Cellular Component

CDC1