A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.

Maftahi M, Hope JC, Delgado-Cruzata L, Han CS, Freyer GA

Our interest in the Schizosaccharomyces pombe RecQ helicase, rqh1+, led us to investigate the function of a related putative DNA helicase, srs2+. We identified the srs2+ homolog in S.pombe, and found that srs2+ is not essential for cell viability. A Deltasrs2 Deltarqh1 double mutant grows extremely slowly with aberrant shaped cells and low viability. This slow growth does not appear ... [more]

Nucleic Acids Res. Nov. 01, 2002; 30(21);4781-92 [Pubmed: 12409469]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SRS2 RAD54	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Trickey M (2008)	Low	-	BioGRID	431985
SRS2 RAD54	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Wang SW (2001)	Low	-	BioGRID	247040

Curated By

BioGRID

Interaction Summary

SRS2

Gene Ontology Biological Process

Gene Ontology Cellular Component

RAD54

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA translocase activity [ISO]protein-DNA loading ATPase activity [TAS]