CDC7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPB1
Gene Ontology Biological Process
- calcium-mediated signaling [IMP]
- cellular chloride ion homeostasis [IMP]
- cellular response to salt stress [IMP]
- cytosolic calcium ion homeostasis [IMP]
- fungal-type cell wall organization or biogenesis [IGI]
- negative regulation of calcium ion transport into cytosol [IMP]
- protein dephosphorylation [IC]
- regulation of conjugation with cellular fusion [IMP]
- regulation of establishment or maintenance of cell polarity regulating cell shape [IMP]
- regulation of mitotic cytokinesis [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Calcineurin is implicated in the regulation of the septation initiation network in fission yeast.
BACKGROUND: In fission yeast, calcineurin has been implicated in cytokinesis because calcineurin-deleted cells form multiple septa and cell separation is impeded. However, this mechanism remains unclear. RESULTS: We screened for mutations that confer synthetic lethality with calcineurin deletion and isolated a mutant, its 10-1/cdc7-i10, a novel allele of the cdc7+ gene involved in the septation initiation network (SIN). The mutation ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: heat sensitivity (APO:0000147)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPB1 CDC7 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 672556 |
Curated By
- BioGRID