TCF7L2
Gene Ontology Biological Process
- blood vessel development [IMP]
- brain development [IBA]
- canonical Wnt signaling pathway [IC]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [IMP]
- cell cycle arrest [IMP]
- cell proliferation [IMP]
- fat cell differentiation [IDA]
- generation of neurons [IBA]
- glucose homeostasis [IDA]
- maintenance of DNA repeat elements [IMP]
- myoblast fate commitment [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- negative regulation of type B pancreatic cell apoptotic process [IDA]
- pancreas development [TAS]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [IMP]
- positive regulation of insulin secretion [IDA, IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein export from nucleus [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of hormone metabolic process [IDA]
- regulation of smooth muscle cell proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to glucose [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IDA, IPI]
- chromatin binding [IBA]
- gamma-catenin binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA, IMP]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IDA, IPI]
- chromatin binding [IBA]
- gamma-catenin binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA, IMP]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
PARP1
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular response to insulin stimulus [IDA]
- double-strand break repair [IMP]
- gene expression [TAS]
- macrophage differentiation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- protein ADP-ribosylation [IDA]
- protein poly-ADP-ribosylation [IDA]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.
Genome-scale expression studies and comprehensive loss-of-function genetic screens have focused almost exclusively on the highest confidence candidate genes. Here, we describe a strategy for characterizing the lower confidence candidates identified by such approaches. We interrogated 177 genes that we classified as essential for the proliferation of cancer cells exhibiting constitutive β-catenin activity and integrated data for each of the candidates, ... [more]
Throughput
- High Throughput
Additional Notes
- High-credibility protein interactions were identified using draft-PPI and a method for protein interaction credibility scoring (ICS).
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TCF7L2 PARP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
PARP1 TCF7L2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
TCF7L2 PARP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID