BAIT
MCM7
SPBC25D12.03c
MCM complex subunit Mcm7
GO Process (0)
GO Function (4)
GO Component (7)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
CHK1
rad27, SPCC1259.13
Chk1 protein kinase
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- mitotic DNA damage checkpoint [IGI]
- mitotic G2 DNA damage checkpoint [IMP]
- negative regulation of transcription from RNA polymerase II promoter by transcription factor localization involved in response to DNA damage checkpoint signaling [IMP]
- peptidyl-serine phosphorylation [IDA]
- signal transduction involved in DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.
MCM proteins are required for the proper regulation of DNA replication. We cloned fission yeast mcm7(+) and showed it is essential for viability; spores lacking mcm7(+) begin S phase later than wild-type cells and arrest with an apparent 2C DNA content. We isolated a novel temperature-sensitive allele, mcm7-98, and also characterized two temperature-sensitive alleles of the fission yeast homolog of ... [more]
Genetics Oct. 01, 2001; 159(2);471-86 [Pubmed: 11606526]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID