BAIT

AIN1

SPAC15A10.08
alpha-actinin
GO Process (4)
GO Function (1)
GO Component (1)
Schizosaccharomyces pombe (972h)
PREY

MYO2

rng5, SPCC645.05c
myosin II heavy chain
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Roles of a fimbrin and an alpha-actinin-like protein in fission yeast cell polarization and cytokinesis.

Wu JQ, Baehler J, Pringle JR

Eukaryotic cells contain many actin-interacting proteins, including the alpha-actinins and the fimbrins, both of which have actin cross-linking activity in vitro. We report here the identification and characterization of both an alpha-actinin-like protein (Ain1p) and a fimbrin (Fim1p) in the fission yeast Schizosaccharomyces pombe. Ain1p localizes to the actomyosin-containing medial ring in an F-actin-dependent manner, and the Ain1p ring contracts ... [more]

Mol. Biol. Cell Apr. 01, 2001; 12(4);1061-77 [Pubmed: 11294907]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: heat sensitivity (APO:0000147)
  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID