serine/threonine protein phosphatase Ppa2
GO Process (3)
GO Function (1)
GO Component (3)
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

Kinoshita N, Yamano H, Niwa H, Yoshida T, Yanagida M

To understand the role of the type 2A-like protein phosphatase in the cell division cycle, we investigated the mutant phenotypes obtained when the fission yeast ppa1+ and ppa2+ phosphatase genes (which encode polypeptides with approximately 80% identity to mammalian type 2A phosphatases) were either deleted or overexpressed. We also investigated the in vivo effect of okadaic acid, an inhibitor of ... [more]

Genes Dev. Jun. 01, 1993; 7(6);1059-71 [Pubmed: 8389306]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)
  • phenotype: heat sensitivity (APO:0000147)

Curated By

  • BioGRID