BAIT
CDC2
cdk1, swo2, tws1, pi002, SPACTOKYO_453.34, wee2, SPBC11B10.09
cyclin-dependent protein kinase Cdk1/Cdc2
GO Process (13)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IMP]
- cellular response to nitrogen starvation [IMP]
- negative regulation of G0 to G1 transition [IMP]
- negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation [IMP]
- negative regulation of induction of conjugation with cellular fusion [EXP]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of mitotic cytokinesis [IMP]
- positive regulation of septation initiation signaling [IMP]
- regulation of cell size [NAS]
- regulation of meiotic cell cycle [IMP]
- response to intra-S DNA damage checkpoint signaling [IMP]
- traversing start control point of mitotic cell cycle [NAS]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
RES2
mcs1, pct1, SPAC22F3.09c
MBF transcription factor complex subunit Res2
GO Process (5)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- regulation of meiotic cell cycle [IMP]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
cdc2 and the regulation of mitosis: six interacting mcs genes.
A cdc2-3w weel-50 double mutant of fission yeast displays a temperature-sensitive lethal phenotype that is associated with gross abnormalities of chromosome segregation and has been termed mitotic catastrophe. In order to identify new genetic elements that might interact with the cdc2 protein kinase in the regulation of mitosis, we have isolated revertants of the lethal double mutant. The suppressor mutations ... [more]
Genetics Aug. 01, 1989; 122(4);773-82 [Pubmed: 2474475]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
Curated By
- BioGRID