PREY

MCS6

cdk7, crk1, mop1, SPBC19F8.07
cyclin-dependent protein kinase/CDK-activating kinase Mcs6
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

cdc2 and the regulation of mitosis: six interacting mcs genes.

Molz L, Booher R, Young P, Beach D

A cdc2-3w weel-50 double mutant of fission yeast displays a temperature-sensitive lethal phenotype that is associated with gross abnormalities of chromosome segregation and has been termed mitotic catastrophe. In order to identify new genetic elements that might interact with the cdc2 protein kinase in the regulation of mitosis, we have isolated revertants of the lethal double mutant. The suppressor mutations ... [more]

Genetics Aug. 01, 1989; 122(4);773-82 [Pubmed: 2474475]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID