BAIT
KLP5
sot1, SPBC2F12.13
kinesin-like protein Klp5
GO Process (6)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RAS1
ste5, SPAC17H9.09c
GTPase Ras1
GO Process (15)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- Cdc42 protein signal transduction [IC]
- conjugation with cellular fusion [IMP]
- establishment or maintenance of cell polarity regulating cell shape [TAS]
- fungal-type cell wall biogenesis [IMP]
- induction of conjugation with cellular fusion [IMP]
- meiotic cell cycle [IMP]
- mitotic cell cycle arrest in response to pheromone [TAS]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter by pheromones [IMP]
- protein localization to plasma membrane [IMP]
- regulation of conjugation with cellular fusion [IMP]
- signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Schizosaccharomyces pombe Ras1 effector, Scd1, interacts with Klp5 and Klp6 kinesins to mediate cytokinesis.
Fission yeast Scd1 is an exchange factor for Cdc42 and an effector of Ras1. In a screen for scd1 interacting genes, we isolated klp5 and klp6, which encode presumptive kinesins. Klp5 and Klp6 form a complex to control the same processes, which so far include microtubule dynamics and chromosome segregation. We showed that klp5 or klp6 inactivation in combination with ... [more]
Genetics Oct. 01, 2003; 165(2);477-88 [Pubmed: 14573463]
Throughput
- Low Throughput
Ontology Terms
- phenotype: heat sensitivity (APO:0000147)
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID