BAIT
KLP5
sot1, SPBC2F12.13
kinesin-like protein Klp5
GO Process (6)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
SHK1
orb2, pak1, SPBC1604.14c
PAK-related kinase Shk1
GO Process (7)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- Cdc42 protein signal transduction [IGI]
- cellular protein localization [IMP]
- establishment or maintenance of actin cytoskeleton polarity [TAS]
- establishment or maintenance of bipolar cell polarity regulating cell shape [IMP]
- positive regulation of establishment of bipolar cell polarity regulating cell shape [IGI]
- regulation of microtubule cytoskeleton organization [IGI]
- regulation of mitotic cytokinesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Schizosaccharomyces pombe Ras1 effector, Scd1, interacts with Klp5 and Klp6 kinesins to mediate cytokinesis.
Fission yeast Scd1 is an exchange factor for Cdc42 and an effector of Ras1. In a screen for scd1 interacting genes, we isolated klp5 and klp6, which encode presumptive kinesins. Klp5 and Klp6 form a complex to control the same processes, which so far include microtubule dynamics and chromosome segregation. We showed that klp5 or klp6 inactivation in combination with ... [more]
Genetics Oct. 01, 2003; 165(2);477-88 [Pubmed: 14573463]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: heat sensitivity (APO:0000147)
Curated By
- BioGRID