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BAIT

MOE1

SPAC637.07

translation initiation factor eIF3d Moe1

GO Process (4)

GO Function (1)

GO Component (5)

Gene Ontology Biological Process

cytoplasmic translational initiation [NAS]

eukaryotic translation initiation factor 3 complex assembly [IMP]

gamma-tubulin complex localization [IMP]

protein complex assembly [IMP]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

eukaryotic 43S preinitiation complex [IDA]

eukaryotic translation initiation factor 3 complex, eIF3e [IDA]

eukaryotic translation initiation factor 3 complex, eIF3m [IDA]

PomBase Entrez Gene RefSeq

Schizosaccharomyces pombe (972h)

PREY

RAS1

ste5, SPAC17H9.09c

GTPase Ras1

GO Process (15)

GO Function (6)

GO Component (8)

Gene Ontology Biological Process

Cdc42 protein signal transduction [IC]

conjugation with cellular fusion [IMP]

establishment or maintenance of cell polarity regulating cell shape [TAS]

fungal-type cell wall biogenesis [IMP]

induction of conjugation with cellular fusion [IMP]

meiotic cell cycle [IMP]

mitotic cell cycle arrest in response to pheromone [TAS]

pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]

positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]

positive regulation of protein localization to nucleus [IMP]

positive regulation of transcription from RNA polymerase II promoter [IDA]

positive regulation of transcription from RNA polymerase II promoter by pheromones [IMP]

protein localization to plasma membrane [IMP]

regulation of conjugation with cellular fusion [IMP]

signal transduction involved in conjugation with cellular fusion [IMP]

Gene Ontology Molecular Function

CTP binding [IDA]
GDP binding [IDA]
GTP binding [IDA]
GTPase activity [IDA]
UTP binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

Cdc42 GTPase complex [TAS]

barrier septum [IDA]

cell division site [IDA]

cytoplasm [IDA]

intracellular [IDA]

plasma membrane [IDA]

PomBase Entrez Gene RefSeq UniprotKB

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation.

Chen CR, Li YC, Chen J, Hou MC, Papadaki P, Chang EC

In fission yeast, Scd1/Ral1 is a putative guanine nucleotide exchange factor for Cdc42sp and also acts as a Ras1 effector necessary for the regulation of cytoskeleton organization. In this study, we have characterized a protein, Moe1, that binds directly to Scd1. A moe1 null (Delta) mutant exhibits numerous phenotypes indicative of abnormal microtubule functioning, including an abnormality in the spindle. ... [more]

Proc. Natl. Acad. Sci. U.S.A. Jan. 19, 1999; 96(2);517-22 [Pubmed: 9892665]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

text only

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
MOE1 RAS1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Papadaki P (2002)	Low	-	BioGRID	246566

Curated By

BioGRID