BAIT
MTCH2
MIMP, SLC25A50, HSPC032
mitochondrial carrier 2
GO Process (1)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Homo sapiens
PREY
GFPT1
CMSTA1, GFA, GFAT, GFAT 1, GFAT1, GFAT1m, GFPT, GFPT1L, MSLG
glutamine--fructose-6-phosphate transaminase 1
GO Process (9)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- UDP-N-acetylglucosamine biosynthetic process [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular protein metabolic process [TAS]
- circadian regulation of gene expression [ISS]
- dolichol-linked oligosaccharide biosynthetic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- energy reserve metabolic process [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.
Genome-scale expression studies and comprehensive loss-of-function genetic screens have focused almost exclusively on the highest confidence candidate genes. Here, we describe a strategy for characterizing the lower confidence candidates identified by such approaches. We interrogated 177 genes that we classified as essential for the proliferation of cancer cells exhibiting constitutive β-catenin activity and integrated data for each of the candidates, ... [more]
Cell Syst Dec. 28, 2015; 3(3);302-316.e4 [Pubmed: 27684187]
Throughput
- High Throughput
Additional Notes
- High-credibility protein interactions were identified using draft-PPI and a method for protein interaction credibility scoring (ICS).
Curated By
- BioGRID