BAIT
RAD26
SPAC9E9.08
ATRIP, ATR checkpoint kinase regulatory subunit Rad26
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Schizosaccharomyces pombe (972h)
PREY
CDC1
mis1, SPAC27E2.05
DNA polymerase delta small subunit Cdc1
GO Process (4)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Mutator phenotype induced by aberrant replication.
We have identified thermosensitive mutants of five Schizosaccharomyces pombe replication proteins that have a mutator phenotype at their semipermissive temperatures. Allele-specific mutants of DNA polymerase delta (poldelta) and mutants of Polalpha, two Poldelta subunits, and ligase exhibited increased rates of deletion of sequences flanked by short direct repeats. Deletion of rad2(+), which encodes a nuclease involved in processing Okazaki fragments, ... [more]
Mol. Cell. Biol. Feb. 01, 1999; 19(2);1126-35 [Pubmed: 9891047]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID