A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54+, a gene involved in the repair of radiation damage and replication fidelity.

Muris DF, Vreeken K, Carr AM, Murray JM, Smit C, Lohman PH, Pastink A

The RAD54 gene of Saccharomyces cerevisiae encodes a putative helicase, which is involved in the recombinational repair of DNA damage. The RAD54 homologue of the fission yeast Schizosaccharomyces pombe, rhp54+, was isolated by using the RAD54 gene as a heterologous probe. The gene is predicted to encode a protein of 852 amino acids. The overall homology between the mutual proteins ... [more]

J. Cell. Sci. Jan. 01, 1996; 109(0);73-81 [Pubmed: 8834792]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Curated By

BioGRID

Interaction Summary

RAD54

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA translocase activity [ISO]protein-DNA loading ATPase activity [TAS]

Gene Ontology Cellular Component

RAD17