A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The fission yeast prp10(+) gene involved in pre-mRNA splicing encodes a homologue of highly conserved splicing factor, SAP155.

Habara Y, Urushiyama S, Tani T, Ohshima Y

In the fission yeast Schizosaccharomyces pombe, 14 prp (pre-mRNAprocessing) mutants have been isolated to date. We cloned the prp10(+) gene by complementation of the temperature-sensitive growth of prp10. Five types of transcripts were found that were alternatively spliced with respect to two possible introns located in the 5'-terminal region. Three of them are probably functional and code for putative proteins ... [more]

Nucleic Acids Res. Dec. 15, 1998; 26(24);5662-9 [Pubmed: 9837997]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PRP10 PRP2	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Banerjee H (2004)	Low	-	BioGRID	-
PRP10 PRP2	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Beales M (2000)	Low	-	BioGRID	-
PRP2 PRP10	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Gozani O (1998)	Low	-	PomBase	-

Curated By

BioGRID

Interaction Summary

PRP2

Gene Ontology Biological Process

Gene Ontology Molecular Function

mRNA binding [ISS]snoRNA binding [TAS]

Gene Ontology Cellular Component

PRP10