BAIT
SSP1
SPCC297.03
Ca2+/calmodulin-dependent (CaMMK)-like protein kinase Ssp1
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- actin filament depolymerization [IGI]
- activation of bipolar cell growth [IMP]
- cellular response to glucose starvation [IMP]
- cellular response to nitrogen starvation [IMP]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- establishment or maintenance of cell polarity regulating cell shape [IMP]
- negative regulation of G0 to G1 transition [IMP]
- signal transduction [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
STY1
phh1, spc1, SPAC24B11.06c
MAP kinase Sty1
GO Process (28)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- G1 cell cycle arrest in response to nitrogen starvation [IMP]
- G1 to G0 transition [IMP]
- MAPK cascade in response to starvation [IMP]
- MAPK cascade involved in osmosensory signaling pathway [IDA, IMP]
- cellular response to cation stress [IGI]
- cellular response to nitrogen starvation [IMP]
- mRNA export from nucleus in response to heat stress [IMP]
- mitotic cell cycle arrest in response to nitrogen starvation [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of transcription factor import into nucleus in response to oxidative stress [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP]
- regulation of DNA binding [IDA]
- regulation of cAMP-mediated signaling [IMP]
- regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of cell shape involved in G1 to G0 transition [IMP]
- regulation of chromatin assembly [IMP]
- regulation of chromatin disassembly [IMP]
- regulation of histone acetylation [IMP]
- regulation of mRNA stability involved in cellular response to UV [IMP]
- regulation of meiotic cell cycle [IMP]
- regulation of reciprocal meiotic recombination [IMP]
- regulation of translation in response to nitrogen starvation [IDA]
- regulation of translation in response to osmotic stress [IDA, IMP]
- regulation of translation in response to oxidative stress [IDA, IMP]
- stress granule assembly [IMP]
- stress granule disassembly [IMP]
- stress-activated MAPK cascade [IMP]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast.
The ssp1 gene encodes a protein kinase involved in alteration of cell polarity in Schizosaccharomyces pombe. ssp1 deletion causes stress sensitivity, reminiscent of defects in the stress-activated MAP kinase, Spc1; however, the two protein kinases do not act through the same pathway. Ssp1 is localized mainly in the cytoplasm, but after a rise in external osmolarity it is rapidly recruited ... [more]
Mol. Biol. Cell May. 01, 1999; 10(5);1495-510 [Pubmed: 10233158]
Throughput
- Low Throughput
Ontology Terms
- cell shape (APO:0000051)
- cell cycle progression (APO:0000253)
- inviable (APO:0000112)
Curated By
- BioGRID