BAIT
UQCRB
MC3DN3, QCR7, QP-C, QPC, UQBC, UQBP, UQCR6, UQPC
ubiquinol-cytochrome c reductase binding protein
GO Process (6)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
AP2A1
ADTAA, AP2-ALPHA, CLAPA1
adaptor-related protein complex 2, alpha 1 subunit
GO Process (13)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- Golgi to endosome transport [NAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- endocytosis [NAS]
- epidermal growth factor receptor signaling pathway [TAS]
- intracellular protein transport [NAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of hyaluronan biosynthetic process [IDA, IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.
Genome-scale expression studies and comprehensive loss-of-function genetic screens have focused almost exclusively on the highest confidence candidate genes. Here, we describe a strategy for characterizing the lower confidence candidates identified by such approaches. We interrogated 177 genes that we classified as essential for the proliferation of cancer cells exhibiting constitutive β-catenin activity and integrated data for each of the candidates, ... [more]
Cell Syst Dec. 28, 2015; 3(3);302-316.e4 [Pubmed: 27684187]
Throughput
- High Throughput
Additional Notes
- High-credibility protein interactions were identified using draft-PPI and a method for protein interaction credibility scoring (ICS).
Curated By
- BioGRID