GM6484
Gene Ontology Biological Process
- cell maturation [IMP]
- cellular lipid metabolic process [IMP, TAS]
- fat cell differentiation [IMP]
- glucose metabolic process [TAS]
- negative regulation of lipoprotein lipase activity [TAS]
- positive regulation of protein processing [ISO]
- regulation of lipid metabolic process [IMP]
- regulation of lipoprotein metabolic process [ISO]
- triglyceride homeostasis [IMP, ISO, TAS]
- type B pancreatic cell proliferation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SQSTM1
Gene Ontology Biological Process
- autophagy [ISO]
- positive regulation of macroautophagy [IBA, ISO]
- positive regulation of protein phosphorylation [ISO]
- protein heterooligomerization [ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of nucleic acid-templated transcription [TAS]
- ubiquitin-dependent protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ.
Excessive nuclear factor-κB (NF-κB) activation mediated by tumor necrosis factor α (TNFα) plays a critical role in inflammation. Here we demonstrate that angiopoietin-like 8 (ANGPTL8) functions as a negative feedback regulator in TNFα-triggered NF-κB activation intracellularly. Inflammatory stimuli induce ANGPTL8 expression, and knockdown or knockout of ANGPTL8 potentiates TNFα-induced NF-κB activation in vitro. Mechanistically, upon TNFα stimulation, ANGPTL8 facilitates the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID