mRNA export receptor, Tap, nucleoporin Mex67
GO Process (2)
GO Function (1)
GO Component (7)
Schizosaccharomyces pombe (972h)


nucleoporin Npp106
GO Process (1)
GO Function (0)
GO Component (5)

Gene Ontology Biological Process

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export.

Yoon JH, Love DC, Guhathakurta A, Hanover JA, Dhar R

We identified the Schizosaccharomyces pombe mex67 gene (spmex67) as a multicopy suppressor of rae1-167 nup184-1 synthetic lethality and the rae1-167 ts mutation. spMex67p, a 596-amino-acid-long protein, has considerable sequence similarity to the Saccharomyces cerevisiae Mex67p (scMex67p) and human Tap. In contrast to scMEX67, spmex67 is essential for neither growth nor nuclear export of mRNA. However, an spmex67 null mutation (Deltamex67) ... [more]

Mol. Cell. Biol. Dec. 01, 2000; 20(23);8767-82 [Pubmed: 11073978]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID