PYP1
Gene Ontology Biological Process
- inactivation of MAPK activity [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- negative regulation of transcription by glucose [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, ISS]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [IMP]
Gene Ontology Molecular Function
PYP2
Gene Ontology Biological Process
- inactivation of MAPK activity [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IGI, IMP]
- negative regulation of stress-activated MAPK cascade [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, IMP, ISS]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [IMP]
- protein dephosphorylation [IGI]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis.
We have used degenerate oligonucleotide probes based on sequences conserved among known protein tyrosine phosphatases (PTPases) to identify two Schizosaccharomyces pombe genes encoding PTPases. We previously described the cloning of pyp1+ (S. Ottilie, J. Chernoff, G. Hannig, C. S. Hoffman, and R. L. Erikson, Proc. Natl. Acad. Sci. USA 88:3455-3459, 1991), and here we describe a second gene, called pyp2+. ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PYP1 PYP2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247624 | |
| PYP2 PYP1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - |
Curated By
- BioGRID