PREY

CDC27

SPBC337.18c, SPBC1734.02c
DNA polymerase delta subunit Cdc27
GO Process (4)
GO Function (2)
GO Component (3)
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Genetic and biochemical analyses of Pfh1 DNA helicase function in fission yeast.

Ryu GH, Tanaka H, Kim DH, Kim JH, Bae SH, Kwon YN, Rhee JS, MacNeill SA, Seo YS

The Schizosaccharomyces pombe pfh1+ gene (PIF1 homolog) encodes an essential enzyme that has both DNA helicase and ATPase activities and is implicated in lagging strand DNA processing. Mutations in the pfh1+ gene suppress a temperature-sensitive allele of cdc24+, which encodes a protein that functions with Schizosaccharomyces pombe Dna2 in Okazaki fragment processing. In this study, we describe the enzymatic properties ... [more]

Nucleic Acids Res. Aug. 11, 2004; 32(14);4205-16 [Pubmed: 15302919]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID