ATF1
Gene Ontology Biological Process
- activation of reciprocal meiotic recombination [IMP]
- cellular response to nitrogen starvation [IMP]
- cellular response to starvation [IMP]
- mRNA export from nucleus in response to heat stress [IMP]
- negative regulation of G1/S transition of mitotic cell cycle by positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation [IMP]
- negative regulation of antisense RNA transcription [IMP]
- negative regulation of reciprocal meiotic recombination [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP]
- nucleosome positioning [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cAMP-mediated signaling [IMP]
- regulation of histone acetylation by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of histone methylation by regulation of transcription from RNA polymerase II promoter [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- RNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- recombination hotspot binding [IDA]
- sequence-specific DNA binding [IDA]
- RNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- recombination hotspot binding [IDA]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
PAP1
Gene Ontology Biological Process
- cellular response to caffeine [IMP]
- cellular response to hydrogen peroxide [IMP]
- cellular response to oxidative stress [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to increased salt [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to menadione [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A cooperative role for Atf1 and Pap1 in the detoxification of the oxidative stress induced by glucose deprivation in Schizosaccharomyces pombe.
In Schizosaccharomyces pombe, glucose concentrations below a certain threshold trigger the stress-activated protein kinase (SAPK) signal transduction pathway and promote increased transcription of Atf1-dependent genes coding for the general stress response. Removal of glucose specifically induces the nuclear accumulation of green fluorescent protein-labeled Pap1 (GFP-Pap1) and the expression of genes dependent on this transcription factor. In contrast, depletion of the ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: oxidative stress resistance (APO:0000083)
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PAP1 ATF1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 1022597 | |
| ATF1 PAP1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | PomBase | - | |
| ATF1 PAP1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 246816 | |
| ATF1 PAP1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | PomBase | - | |
| ATF1 PAP1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 246457 | |
| PAP1 ATF1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | PomBase | 882948 | |
| ATF1 PAP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | PomBase | - | |
| PAP1 ATF1 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 667953 |
Curated By
- BioGRID