A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Genetic interaction between calcineurin and type 2 myosin and their involvement in the regulation of cytokinesis and chloride ion homeostasis in fission yeast.

Fujita M, Sugiura R, Lu Y, Xu L, Xia Y, Shuntoh H, Kuno T

Calcineurin plays a critical role in Ca(2+) signaling in various cell types. In fission yeast, calcineurin is required for cytokinesis and chloride ion homeostasis. However, most of its physiological functions remain obscure. A genetic screen was performed to identify genes that share an essential function with calcineurin. We screened for mutations that confer sensitivity to the calcineurin inhibitor FK506 and ... [more]

Genetics Jul. 01, 2002; 161(3);971-81 [Pubmed: 12136004]

Throughput

Low Throughput

Ontology Terms

phenotype: resistance to chemicals (APO:0000087)

Additional Notes

Overexpression of truncated PPB1 rescues growth of MYO3 mutants in high MgCl2 media

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PPB1 MYP2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Fujita M (2002)	Low	-	BioGRID	435224

Curated By

BioGRID

Interaction Summary

PPB1

Gene Ontology Biological Process

Gene Ontology Molecular Function

calcium-dependent protein serine/threonine phosphatase activity [IMP]phosphatase activity [IDA]

Gene Ontology Cellular Component

MYP2