BAIT
ALP14
mtc1, SPCC895.07
TOG ortholog Alp14
GO Process (6)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IDA]
- cytoplasmic microtubule organization [IMP]
- establishment or maintenance of cell polarity regulating cell shape [IMP]
- microtubule cytoskeleton organization [IMP]
- mitotic sister chromatid segregation [IMP]
- spindle assembly involved in mitosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
MIS12
SPBC409.04c
kinetochore protein Mis12
GO Process (3)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
M phase-specific kinetochore proteins in fission yeast: microtubule-associating Dis1 and Mtc1 display rapid separation and segregation during anaphase.
BACKGROUND: Kinetochore microtubules are made early in mitosis and link chromosomal kinetochores to the spindle poles. They are required later to move the separated sister chromatids toward the opposite poles upon the onset of anaphase. Very little is known about proteins that are responsible for the connection between kinetochores and mitotic microtubules. RESULTS: We here show that fission yeast Dis1 ... [more]
Curr. Biol. Apr. 17, 2001; 11(8);537-49 [Pubmed: 11369198]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID