PYP1
Gene Ontology Biological Process
- inactivation of MAPK activity [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- negative regulation of transcription by glucose [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, ISS]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [IMP]
Gene Ontology Molecular Function
PYP2
Gene Ontology Biological Process
- inactivation of MAPK activity [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IGI, IMP]
- negative regulation of stress-activated MAPK cascade [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, IMP, ISS]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [IMP]
- protein dephosphorylation [IGI]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast.
We have identified a third protein tyrosine phosphatase (PTPase) gene in fission yeast, pyp2, encoding an 85 kDa protein. Disruption of pyp2 has no impact on cell viability, but pyp2 is essential in strains lacking the 60 kDa pyp1 PTPase. The two pyp PTPases are approximately 42% identical in their C-terminal catalytic domains and share weak homology in their N-terminal ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PYP2 PYP1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - | |
| PYP1 PYP2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247422 |
Curated By
- BioGRID