PGRP-LE
Gene Ontology Biological Process
- defense response [NAS]
- defense response to Gram-negative bacterium [IGI, IMP]
- defense response to Gram-positive bacterium [IDA]
- defense response to bacterium [IMP]
- determination of adult lifespan [IMP]
- immune response [IMP, ISS, TAS]
- peptidoglycan catabolic process [IKR]
- peptidoglycan recognition protein signaling pathway [IDA]
- positive regulation of innate immune response [IMP]
- response to bacterium [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PGRP-LE
Gene Ontology Biological Process
- defense response [NAS]
- defense response to Gram-negative bacterium [IGI, IMP]
- defense response to Gram-positive bacterium [IDA]
- defense response to bacterium [IMP]
- determination of adult lifespan [IMP]
- immune response [IMP, ISS, TAS]
- peptidoglycan catabolic process [IKR]
- peptidoglycan recognition protein signaling pathway [IDA]
- positive regulation of innate immune response [IMP]
- response to bacterium [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling.
In the Drosophila immune response, bacterial derived diaminopimelic acid-type peptidoglycan binds the receptors PGRP-LC and PGRP-LE, which through interaction with the adaptor protein Imd leads to activation of the NF-κB homolog Relish and robust antimicrobial peptide gene expression. PGRP-LC, PGRP-LE, and Imd each contain a motif with some resemblance to the RIP Homotypic Interaction Motif (RHIM), a domain found in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PGRP-LE PGRP-LE | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| PGRP-LE PGRP-LE | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | FlyBase | - | |
| PGRP-LE PGRP-LE | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | FlyBase | - | |
| PGRP-LE PGRP-LE | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |