myo3, SPAC4A8.05c
myosin II heavy chain Myo3
GO Process (3)
GO Function (1)
GO Component (3)
Schizosaccharomyces pombe (972h)


bub2, SPAC6F6.08c
two-component GAP Cdc16
GO Process (3)
GO Function (2)
GO Component (3)
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Identification of a second myosin-II in Schizosaccharomyces pombe: Myp2p is conditionally required for cytokinesis.

Bezanilla M, Forsburg SL, Pollard TD

As in many eukaryotic cells, fission yeast cytokinesis depends on the assembly of an actin ring. We cloned myp2(+), a myosin-II in Schizosaccharomyces pombe, conditionally required for cytokinesis. myp2(+), the second myosin-II identified in S. pombe, does not completely overlap in function with myo2(+). The catalytic domain of Myp2p is highly homologous to known myosin-IIs, and phylogenetic analysis places Myp2p ... [more]

Mol. Biol. Cell Dec. 01, 1997; 8(12);2693-705 [Pubmed: 9398685]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)
  • phenotype: heat sensitivity (APO:0000147)

Curated By

  • BioGRID