WEE1
Gene Ontology Biological Process
- cytokinesis after mitosis checkpoint [IGI]
- mitotic DNA damage checkpoint [IMP]
- mitotic cell cycle checkpoint [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IDA]
- peptidyl-serine autophosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IDA]
- regulation of cell size [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SRW1
Gene Ontology Biological Process
- mitotic cell cycle arrest in response to nitrogen starvation [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IC]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes.
In the fission yeast Schizosaccharomyces pombe, p34(cdc2) plays a central role controlling the cell cycle. We recently isolated a new gene named srw1(+), capable of encoding a WD repeat protein, as a multicopy suppressor of hyperactivated p34(cdc2). Cells lacking srw1(+) are sterile and defective in cell cycle controls. When starved for nitrogen source, they fail to effectively arrest in G1 ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- genetic complex
- overexpression of srw1 rescues the lethality of a rad3/wee1 double mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WEE1 SRW1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 2535000 | |
| SRW1 WEE1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247641 | |
| SRW1 WEE1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247706 |
Curated By
- BioGRID