A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity.

Snaith HA, Brown GW, Forsburg SL

The fission yeast Hsk1p kinase is an essential activator of DNA replication. Here we report the isolation and characterization of a novel mutant allele of the gene. Consistent with its role in the initiation of DNA synthesis, hsk1(ts) genetically interacts with several S-phase mutants. At the restrictive temperature, hsk1(ts) cells suffer abnormal S phase and loss of nuclear integrity and ... [more]

Mol. Cell. Biol. Nov. 01, 2000; 20(21);7922-32 [Pubmed: 11027263]

Throughput

Low Throughput

Ontology Terms

phenotype: heat sensitivity (APO:0000147)
phenotype: vegetative growth (APO:0000106)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDC23 HSK1	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Lee JK (2003)	Low	-	BioGRID	-
CDC23 HSK1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Liang DT (2001)	Low	-	BioGRID	247194

Curated By

BioGRID

Interaction Summary

HSK1

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [IDA]protein binding [IPI]protein kinase activity [IDA]protein serine/threonine kinase activity [IDA]

Gene Ontology Cellular Component

CDC23

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA primase activity [IDA]protein binding [IPI]single-stranded DNA binding [IDA]