BAIT

HSK1

cdc7, SPBC776.12c
Dbf4(Dfp1)-dependent protein kinase Hsk1
Schizosaccharomyces pombe (972h)
PREY

RAD21

SPCC338.17c
mitotic cohesin complex, non-SMC subunit Rad21 (kleisin)
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity.

Snaith HA, Brown GW, Forsburg SL

The fission yeast Hsk1p kinase is an essential activator of DNA replication. Here we report the isolation and characterization of a novel mutant allele of the gene. Consistent with its role in the initiation of DNA synthesis, hsk1(ts) genetically interacts with several S-phase mutants. At the restrictive temperature, hsk1(ts) cells suffer abnormal S phase and loss of nuclear integrity and ... [more]

Mol. Cell. Biol. Nov. 01, 2000; 20(21);7922-32 [Pubmed: 11027263]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
HSK1 RAD21
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
247602

Curated By

  • BioGRID